Migraine and Calcitonin Gene-Related Peptide Receptor Antagonist Treatment
نویسندگان
چکیده
منابع مشابه
Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.
BACKGROUND Calcitonin gene-related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP-receptor antagonist might be effective in the treatment of migraine attacks. METHODS In an international, multicenter, double-blind, randomized clinical trial of BIBN 4096 BS, a highly specific and potent nonpeptide CGRP-receptor antagonist, 126 patients with migraine...
متن کاملCalcitonin gene - related peptide and migraine
Recent findings CGRP is widely distributed in the nervous system, particularly at anatomical areas thought to be involved with migraine, including the trigeminovascular nociceptive system. In studies, CGRP has been shown to be released during severe migraine attacks, and effective triptan treatment of an attack normalizes these levels. CGRP administration triggers migraine in patients and CGRP ...
متن کاملCalcitonin gene-related peptide receptor antagonist human CGRP-(8-37).
From this study, we predicted that the human calcitonin gene-related peptide (hCGRP) fragment hCGRP-(8-37) would be a selective antagonist for CGRP receptors but an agonist for calcitonin (CT) receptors. In rat liver plasma membrane, where CGRP receptors predominate and CT appears to act through these receptors, hCGRP-(8-37) dose dependently displaced 125I-[Tyr0]rat CGRP binding. However, hCGRP...
متن کاملCalcitonin gene-related peptide and its role in migraine pathophysiology.
Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded that: (i) CGRP may have an important role in migraine pathophysiology, and (ii) inhibition...
متن کاملCalcitonin gene related peptide (CGRP)-provoked migraine-like attacks.
In this issue of Cephalalgia, Dr Jakob Moller Hansen and his colleagues report a series of very interesting experiments in which they successfully induced migraine-like attacks in patients with migraine with aura via infusion of calcitonin gene related peptide (CGRP). This work echoes similar experiments carried out by the Copenhagen group using the nitric oxide donor, glycerol trinitrate (GTN)...
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ژورنال
عنوان ژورنال: Journal of Experimental and Basic Medical Sciences
سال: 2020
ISSN: 2717-9478
DOI: 10.5606/jebms.2020.75617